Effects of pioglitazone on erectile dysfunction in sildenafil poor-responders: a randomized, controlled study

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Effects of pioglitazone on erectile dysfunction in sildenafil poor-responders: a randomized, controlled study.

PURPOSE The effects of pioglitazone on sildenafil responsiveness in men with erectile dysfunction(ED) and a history of poor response to sildenafil were assessed. METHODS In a double-blinded study,38 men aged 47 +/- 1.5 years with moderate-to severe ED and poor response to sildenafil were randomly assigned to take a premedication of pioglitazone 30 mg (n=19) or placebo (n=19) once daily for 9 ...

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Sildenafil effects on exercise, neurohormonal activation, and erectile dysfunction in congestive heart failure: a double-blind, placebo-controlled, randomized study followed by a prospective treatment for erectile dysfunction.

BACKGROUND Erectile dysfunction (ED) is common in patients with congestive heart failure (CHF). ED reduces quality of life, and it may affect compliance, thereby impairing the success of CHF treatment. METHODS AND RESULTS In the first phase (fixed-dose double-blind, randomized, placebo-controlled, two-way crossover study), we studied in 23 men with CHF the effects of 50 mg sildenafil on exerc...

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Efficacy and tolerability of sildenafil in Indian males with erectile dysfunction: A double-blind, randomized, placebo- controlled, crossover study

Sir, A randomized, double-blind, placebo-controlled, crossover study was conducted over one year to assess whether sildenafil (50 mg) is effective in Indian males. Fifty-nine patients in the age group 18 to 60 years with erectile dysfunction (ED) for more than 6 months completed the study. The sexual partners were also questioned during and after the study period. The subjects underwent either ...

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Flexible Multi-dose GnRH Antagonist versus Long GnRH Agonist Protocol in Poor Responders: A Randomized Controlled Trial

Background To compare a flexible, multi-dose GnRH antagonist protocol with a long GnRH .agonist protocol in poor respo MaterialsAndMethods A randomized clinical trial of 70 poor responder patients (35 patients in GnRH antagonist protocol and 35 patients in long GnRH agonist protocol) was performed at Royan Institute, Tehran, Iran. Both groups were given a fixed dose of human menopausal gonadotr...

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Oral sildenafil in the treatment of erectile dysfunction. Sildenafil Study Group.

BACKGROUND Sildenafil is a potent inhibitor of cyclic guanosine monophosphate hydrolysis [corrected] in the corpus cavernosum and therefore increases the penile response to sexual stimulation. We evaluated the efficacy and safety of sildenafil, administered as needed in two sequential double-blind studies of men with erectile dysfunction of organic, psychogenic, and mixed causes. METHODS In a...

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ژورنال

عنوان ژورنال: Journal of Pharmacy & Pharmaceutical Sciences

سال: 2008

ISSN: 1482-1826,1482-1826

DOI: 10.18433/j3tg6h